![]() Misfolded proteins are involved in the etiology of many diseases, including neural degenerations ( 1, 2), lysosome storage disorders ( 3), cystic fibrosis ( 4), and type II diabetes ( 5), as well as visual disorders including retinitis pigmentosa (RP ref. Collectively, we provide proof of principle that nonretinoid chaperones are promising drug candidates in treating RHO-associated RP. In vivo, intravitreal injection of YC-001 or F5257-0462 microparticles in PBS shows that F5257-0462 has a higher efficacy in preserving photoreceptor function and delaying photoreceptor death in Rho P23H/+ mice. Similarly, F5257-0462 also protects photoreceptors in Rho P23H/+ retinal explants. Interestingly, YC-001 ameliorated retinal immune responses and reduced the number of microglia/macrophages in the Rho P23H/+ retinal explants. Furthermore, using retinal explant culture, we show that YC-001 improves retinal proteostasis by supporting RHO homeostasis in Rho P23H/+ mouse retinae, which results in thicker outer nuclear layers (ONL), indicating delayed photoreceptor degeneration. ![]() Here, we profile the chaperone activities of these molecules toward the cell-surface level of 27 RP-causing human RHO mutants in NIH3T3 cells. We previously identified nonretinoid chaperones of RHO, including YC-001 and F5257-0462, by small-molecule high-throughput screening. RHO protein misfolding leads to disturbed proteostasis and the death of rod photoreceptors, resulting in decreased vision. Registrant Organization: Global iNet World, Inc.Rhodopsin-associated ( RHO-associated) retinitis pigmentosa (RP) is a progressive retinal disease that currently has no cure. Registrar: CSL Computer Service Langenbach GmbH d/b/a Registry Domain ID: 1886734081_DOMAIN_COM-VRSN ![]() ![]() *** hijinks ensue! TAGS: small ***,3d loli ***,***,large ***,mom son ***,futa,3d,3d cartoon ***,hippy hills comix,***,crazy 3d *** world,father daughter ***,teen ***,*** comix,*** *** art galleries,crazy ***,taboo 3d comics,exspansion,cyber ***,3d toons *** crazy,femboy,3d *** free,feedee,*** comics online,howell clinic,the chaperone,3d *** central,old young ***,vampires,big ***,clara ravens comix,craz圓d,crazyxx3d comics,ssbbw,e-books,*** cartoons,pregnancy,anime,*** love,carnal clinic comic,fem32,*** 3d cartoon,six gun sisters comix,2d *** comic,*** *** art pictures,fem-32,*** 3d,crazy 3d ***,crazy 3d world,langsuirs comix,3d ***,foodee,crazy 3dxxx world,Brother Sister ***,3d *** pics,tiny ***,xxx3dworld,crazy *** 3d world,battleforce comix,cgi 3d ***,crazyxxx3d,epoch,habitat 5,trap,3d crazy *** comics,auditor of reality,3d *** pictures,stuffing,taboo ***,xxx3d,inflation,crazy 3d ***,free preg cartoon ***,milking,3d *** crazy toons,3d fantasy anime ***,neue rasse 3d comic,malevolent intentions comix,bdsm cartoon,bro sis ***,violence ***,3dcomics,zombies,family *** 3d comics,*** comix,*** 3d ***,free *** 3d comics,tentacles,fantasy ***,3d world,lactation,3d lolitas ***,3d comix,*** young ***,nudists,crazyxxx3dworld,3d stories,***,craz圓d.com,3dworld,3d ***,echo comics,futanari,poochy,fat,chubby,uninhibited comix,monster ***,crazy 3d ***,alien abduction,family ***,vox populi comix,3d ***,milfs,ebooks,taboo ***,*** *** 3d comics,3d crazy world,nudist,圓df,3d *** comic,pregnant,*** comics and cartoons,freehope comic,comix 3d,plumpers,gaining,teen ***,***,habitat5,3d pervert,interactive ***,animations,dad 3d,3dporn,men in black,alien ***,2d *** comics,jag *** cartoon comic mom,mom tarts,weight gain,jag27,jag,3d orgies,crazyxxx,3d *** pictures,*** ***,3d ***,otto maddox,virtual 3d world,free 3d *** pics,young teens ***,crazy *** 3d comics,craz圓dworld,legacy comic,cougar,3d *** art,virtual *** When a woman going through a rough divorce is forced to move in with her mother who manages a nudist resort. or join up with the perverts running the place? Only time will tell. and one unsuspecting family has just landed in the middle of it. ![]() Something sinister is going on behind the scenes. Description: The Hippy Hills Naturalist Resort is more than just a camp for nudists. ![]()
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